News

Job offers

PhD
Are you a highly motivated PhD student, wanting to focus on the field of bioinformatics and biomedicine to study immunological landscapes by microscopy and mass spectrometry imaging datasets? Then we are looking for you. Please refer to this job offer for further details.

Hot Stuff

2020

Publication accepted in "Mucosal Immunology"

The renowned journal Mucosal Immunology has accepted our paper "Spatial proteomics revealed a CX3CL1-dependent crosstalk between the urothelium and relocated macrophages through IL-6 during an acute bacterial infection in the urinary bladder" in which our algorithm SPRING (Spatial PRoteome ImagING) revealed the impact and the mechanism of macrophage migration into the infected urothelium during urinary tract infection. SPRING (Spatial PRoteome ImagING) A novel algorithm for correlative mass spectrometry imaging and microscopy which has been developed by our group.

2019
Proteome (MALDI MSI) study on macrophage relocation available! https://www.biorxiv.org/content/10.1101/649137v1 Congrats to Jenny and Camille: Our algorithm SPRING (Spatial PRoteome ImagING) revealed the impact and the mechanism of macrophage migration into the infected urothelium during urinary tract infection. Highlights

1. Macrophages relocate into the urothelium upon infection

2. Spatial expression of Tim3 and Myo9b correlates with macrophage infiltrates

3. A novel algorithm for correlative mass spectrometry imaging and microscopy identifies IL-6–induced CX3CL1 production by urothelial cells as the critical molecule for relocation of macrophages

4. Macrophages maintain urothelial barrier function by elimination of neutrophils and uropathogenic E.coli

 

 

 

Editorial on myeloid cells in EAE In the upcoming issue of the Journal of Leukocyte Biology.

2018

Establishment of Spatial Proteome Imaging in cancer  Jenny Bottek and Camille Soun have managed to analyze the proteome on histological sections by MALDI Imaging.  We are now starting to measure clinical samples for prediction of therapy resistance and biomarker discovery in cancer. The latest work from the lab is out (Frontline research) in volume 103, issue 1 of Journal of Leukocyte Biology. The study "Proliferation of Ly6C+ monocytes during urinary tract infections is regulated by IL-6 trans-signalling" was headed by our former graduate student Akanksha Dixit, now working in Bonn, and supported by various co-authors. CONGRATULATIONS!

2017

Video of the Immunodynamics group in "Gut"

We are proud to present you with a video which the renowned journal Gut had asked us to produce alongside the paper published recently regarding new findings on POI.

Immunodynamics on Twitter and Facebook

For more up to date info, you can now also follow us on Twitter - twitter.com\drengellab - as well as on Facebook - facebook.com/immunodynamics

Amazing imaging of blood vessels within organs

Have a look at todays amazing imaging possibilities of blood vessels within organs. Such images are being visualized at the Institute for Experimental Immunology and Imaging, Department of Immunodynamics.

LichtscheibenmikroskopieWahnsinn, wie man heute Blutgefäße in Organen sichtbar machen kann #Lichtscheibenmikroskopie . Könnt ihr das Organ erkennen? Solche Aufnahmen entstehen im Institut für Experimentelle Immunologie und Bildgebung, Abteilung Immundynamik http://bit.ly/2A8Wg6F Posted by Universitätsklinikum Essen on Thursday, 2 November 2017

Publication in "JLB"

Our paper dealing with new findings regarding the proliferation of Ly6C+ monocytes was accepted in the Journal of Leukocyte Biology (doi:10.1189/jlb.3HI0517-198R). This study was headed by our former PhD student Akanksha Dixit and we would like to thank all coauthors for their valuable contribution. Please find the whole paper "Proliferation of Ly6C+ monocytes during urinary tract infections is regulated by IL-6 trans-signaling" on our publication section.

Publication in "Gut"

Please find the press announcement (German version) regarding the paper "Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus."

Publication in "Gut"

We are very proud to announce that our paper dealing with new findings regarding the postoperative Ileus was accepted in the renowned journal Gut (doi:10.1136/gutjnl-2017-313856). This study is headed by our PhD student Judith-Mira Pohl and we would like to thank all coauthors for their valuable contribution. Please find the press announcement (German version) regarding the paper "Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus."

Development of SCHNELL

Our Bioinformatic group, Camille, has started to develop SCHNELL, a program to Statistically Compute Histology Networks to Enable Leukocyte Localization.

MALDI Imaging Data in collaboration with the ZeTeM in Bremen

In collaboration with the ZeTeM, we could generate first proteome data on UPEC-infected urinary bladders by MALDI Imaging. This is a first milestone for finding novel biomarkers in this frequent infection.

Current Lectures, Practical Courses & Seminars

2020/2021

Lectures 2020/2021

* Physiology (SuSe 2020)

* Basic concepts in Immunology (WiSe 2020/21)

* NEW: Modern Microscopy Techniques (SuSe 2020)

Lecture for master students of medical biology starting 10th April. Every Wednesday in the semester from 14:00h for about 1,5h.

Due to the Corona virus situation lectures and practical courses will take place via Zoom. Students to refer to the specific Moodle space for detailed information.

Practical Courses 2020/2021

♦ Physiology-Seminar (SuSe 2020) Lecture related seminar for bachelor students of bio-medicine in which the students will put their theoretical knowledge to practical presentations and discussions.

♦ Basic concepts in Immunology-Seminar (WiSe 2020/21)

Research Seminar 2020/2021 The Research Seminar takes place monthly during the semester (Fridays 09:00 - 10:00h) and focuses on biomedical research projects. It is aimed at the various research groups of the Medical Research Center (MFZ) and BIOME students. Attendance of the seminar is granted credits for the BIOME students - in order to collect those, please bring the "BIOME Additional Lectures - Attendance Sheet" with you that you need to fill out and get signed by Prof. Engel. The current scope of the seminar is a 25 minute talk followed by a 5 minute discussion.

2019/2020

Lectures 2019/2020

* Physiology (SuSe 2019)

* Basic concepts in Immunology (WiSe 2019/20)

* NEW: Modern Microscopy Techniques (SuSe 2019) Lecture for master students of medical biology starting 10th April 2019; every Wednesday in the semester from 14:00h for about 1,5h. List of place and themes will follow soon.

Practical Courses 2019/2020

♦ Physiology-Seminar (SuSe 2019) Lecture related seminar for bachelor students of bio-medicine in which the students will put their theoretical knowledge to practical presentations and discussions. The introductory session took place 8th April 2019 in the seminar room 0.019 of the MFZ at UK Essen.

♦ Basic concepts in Immunology-Seminar (WiSe 2019/20)

Research Seminar 2019/2020

The Research Seminar takes place monthly during the semester and focuses on biomedical research projects. It is aimed at the various research groups of the Medical Research Center (MFZ) and BIOME students. Attendance of the seminar is granted credits for the BIOME students - in order to collect those, please bring the "BIOME Additional Lectures - Attendance Sheet" with you that you need to fill out and get signed by Prof. Engel. The current scope of the seminar is a 25 minute talk followed by a 5 minute discussion. Please find the annual schedule here: Summer Semester 2019& Winter Semester 2019/2020. Please refer to the NEWS section of the Immunodynamics Homepage to update yourselves regarding changes of talks and speakers.

Tuesday Seminars (Engel & Gunzer)

Every Tuesday, we conduct an internal seminar on the ongoing research projects.