Proteome (MALDI MSI) study on macrophage relocation available!

Congrats to Jenny and Camille: Our algorithm SPRING (Spatial PRoteome ImagING) revealed the impact and the mechanism of macrophage migration into the infected urothelium during urinary tract infection.


1. Macrophages relocate into the urothelium upon infection

2. Spatial expression of Tim3 and Myo9b correlates with macrophage infiltrates

3. A novel algorithm for correlative mass spectrometry imaging and microscopy identifies IL-6–induced CX3CL1 production by urothelial cells as the critical molecule for relocation of macrophages

4. Macrophages maintain urothelial barrier function by elimination of neutrophils and uropathogenic E.coli

Two Bachelor students will start beginning of April to study the proliferation of urothelial cells in UPEC infection and the mechanisms of endothelial injury in shiga-toxin-mediated kidney diseases

PhD Doctorate in Chronic lymphocytic leukemia
Nirojah Vijitha managed her PhD defense in March 2019 with an excellent grade. She studied the mechanisms of infections in CLL patients and will continue this project as a Postdoc scientist. Congratulations Niro!


Bachelor Thesis on urothelial cells in UPEC infection
Starting in mid March, Bachelor Student Marie Jakobs started the practical section of her studies in our lab. She aims at studying uroepithelial cells after UPEC infection in vitro and in vivo by employing FACS and microscopy. Marie is being supported by our M.Sc. Jenny Bottek.


Research Assistant Bioinformatics starting August 1st
Camille Soun started as a graduate student of BioImaging and worked as student assistant in our group from January until June 2017 . In the course of her work at our department, devising ways to master the innumerable research data, we have decided that it would make sense to set up the position of a Research Assistant with emphasis on Bioinformatics. Camille underwent the obligatory recruitment process and due to her outstanding skills in this area we are happy to welcome her on board as of August 1st, 2017.

PhD Doctorates
Judith-Mira Pohl managed her PhD defense with the outstanding grade summa cum laude in September 2017 after 5 years of diligent studying and researching. Judith has studied the role of Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome in postoperative ileus which was published in the renowned journal "Gut" (IF 16.7). CONGRATULATIONS!

After nearly 5 years of relentless studying and researching, Akanksha Dixit managed her PhD defense successfully 29th May 2017 and has received her PhD certificate 11th July 2017. CONGRATULATIONS!

Bachelor Thesis
Beginning in April, Bachelor Student Nils Kirstein started the practical section of his studies in our lab. He aims at studying alveolar macrophages during bacterial infections.   Nils will employ flow cytometry and fluorescence microscopy to study alveolar macrophages in vitro and in vivo.  Nils is being supported by our PhD student Kristina Zec. Nils finished his Bachelor thesis in October 2017 and passed with an outstanding 1.0.

PhD thesis "Crosstalk of Neutrophils and Macrophages" has started 
In January, Julia Volke has started her PhD thesis on the role of Macrophages in regulating the functionality of Neutrophils. This study was granted by the DFG and is a follow up story on the recent findings, which were published in our Cell Paper (doi:10.1016/j.cell.2014.01.006).

Hot Stuff


Editorial on myeloid cells in EAE
In the upcoming issue of the Journal of Leukocyte Biology.


Establishment of Spatial Proteome Imaging in cancer 
Jenny Bottek and Camille Soun have managed to analyze the proteome on histological sections by MALDI Imaging.  We are now starting to measure clinical samples for prediction of therapy resistance and biomarker discovery in cancer.

The latest work from the lab is out (Frontline research) in volume 103, issue 1 of Journal of Leukocyte Biology. The study "Proliferation of Ly6C+ monocytes during urinary tract infections is regulated by IL-6 trans-signalling" was headed by our former graduate student Akanksha Dixit, now working in Bonn, and supported by various co-authors. CONGRATULATIONS!


Video of the Immunodynamics group in "Gut"
We are proud to present you with a video which the renowned journal Gut had asked us to produce alongside the paper published recently regarding new findings on POI.

Immunodynamics on Twitter and Facebook
For more up to date info, you can now also follow us on Twitter -\drengellab - as well as on Facebook -

Amazing imaging of blood vessels within organs
Have a look at todays amazing imaging possibilities of blood vessels within organs. Such images are being visualized at the Institute for Experimental Immunology and Imaging, Department of Immunodynamics.

LichtscheibenmikroskopieWahnsinn, wie man heute Blutgefäße in Organen sichtbar machen kann #Lichtscheibenmikroskopie . Könnt ihr das Organ erkennen? Solche Aufnahmen entstehen im Institut für Experimentelle Immunologie und Bildgebung, Abteilung Immundynamik

Posted by Universitätsklinikum Essen on Thursday, 2 November 2017


Publication in "JLB"
Our paper dealing with new findings regarding the proliferation of Ly6C+ monocytes was accepted in the Journal of Leukocyte Biology (doi:10.1189/jlb.3HI0517-198R). This study was headed by our former PhD student Akanksha Dixit and we would like to thank all coauthors for their valuable contribution. Please find the whole paper "Proliferation of Ly6C+ monocytes during urinary tract infections is regulated by IL-6 trans-signaling" on our publication section.

Publication in "Gut"
We are very proud to announce that our paper dealing with new findings regarding the postoperative Ileus was accepted in the renowned journal Gut (doi:10.1136/gutjnl-2017-313856). This study is headed by our PhD student Judith-Mira Pohl and we would like to thank all coauthors for their valuable contribution. Please find the press announcement (German version) regarding the paper "Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus."

Development of SCHNELL
Our Bioinformatic group, Camille, has started to develop SCHNELL, a program to Statistically Compute Histology Networks to Enable Leukocyte Localization.

MALDI Imaging Data in collaboration with the ZeTeM in Bremen
In collaboration with the ZeTeM, we could generate first proteome data on UPEC-infected urinary bladders by MALDI Imaging. This is a first milestone for finding novel biomarkers in this frequent infection.

Press release


Publication in "Gut"
Please find the press announcement (German version) regarding the paper "Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus."


Current Lectures, Practical Courses & Seminars


Lectures 2019/2020
* Physiology (SuSe 2019)
* Basic concepts in Immunology (WiSe 2019/20)
* NEW: Modern Microscopy Techniques (SuSe 2019)
Lecture for master students of medical biology starting 10th April 2019; every Wednesday in the semester from 14:00h for about 1,5h. List of place and themes will follow soon.

Practical Courses 2019/2020
♦ Physiology-Seminar (SuSe 2019)
Lecture related seminar for bachelor students of bio-medicine in which the students will put their theoretical knowledge to practical presentations and discussions. The introductory session took place 8th April 2019 in the seminar room 0.019 of the MFZ at UK Essen. Please find here the list of dates and themes incl. the names of students to present during the seminar.

♦ Basic concepts in Immunology-Seminar (WiSe 2019/20)

Research Seminar 2019/2020
The Research Seminar takes place monthly during the semester and focuses on biomedical research projects. It is aimed at the various research groups of the Medical Research Center (MFZ) and BIOME students. Attendance of the seminar is granted credits for the BIOME students - in order to collect those, please bring the "BIOME Additional Lectures - Attendance Sheet" with you that you need to fill out and get signed by Prof. Engel. The current scope of the seminar is a 25 minute talk followed by a 5 minute discussion. Please find the annual schedule here: Summer Semester 2019& Winter Semester 2019/2020.

Please refer to the NEWS section of the Immunodynamics Homepage to update yourselves regarding changes of talks and speakers.

Tuesday Seminars (Engel & Gunzer)
Every Tuesday, we conduct an internal seminar on the ongoing research projects.