Publications

Most Important Publications

Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus

Pohl, JM, ... , Engel, DR 

Gut  ePub ahead of print (2017)

 

 

 

Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages

Zec, K, ... , Engel, DR 

Pathogens  6 (2016)

Cx3cr1 Reduces Kidney Fibrosis by Inhibiting Local Proliferation of Profibrotic Macrophages

Engel, DR et al.

J Immunol  194, 1628-38 (2015)

Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes

Hasenberg, A, ... , Engel, DR, ... , Gunzer, M

Nat Methods  (2015)

Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium

Schiwon, M, ... , Engel, DR

Cell  156, 456-468 (2014)

Schiwon_Cell_2014

Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression

Hochheiser, K, ... , Engel, DR, Tharaux, PL, Kurts, C

J Clin Invest 123, 4242-4254 (2013)

Bildschirmfoto 2014-03-23 um 16.55.12

IL-6 Controls the Innate Immune Response against Listeria monocytogenes via Classical IL-6 Signaling

Hoge, J, ... , Engel, DR, Scheller, J, Rose-John, S, Mittrucker, HW

J Immunol 190, 703-711, (2013)

Bildschirmfoto 2014-03-23 um 16.32.39

Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice

Tittel, AP, ... , Engel, DR, Garbi, N, Kurts, C

Nat Methods 9, 4, 385-90 (2012)

Bildschirmfoto 2014-03-23 um 16.40.50

Renal dendritic cells adopt a pro-inflammatory phenotype in obstructive uropathy to activate T cells but do not directly contribute to fibrosis

Snelgrove, SL , ... , Engel, DR* , Kitching, AR*       *equally contributed

Am J Pathol 180, 91-103 (2012)

Bildschirmfoto 2014-03-23 um 16.38.16

T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract

Engel, DR , ... , Kurts, C

Nat Med 16, 1407-1413 (2010)

Bildschirmfoto 2014-03-23 um 16.40.50

CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection

Engel, DR , ... , Kurts, C

J Immunol 181, 5579-5586 (2008)

Bildschirmfoto 2014-03-23 um 16.43.20

Complete list of Publications

2017

Pohl JM, Gutweiler S, Thiebes S, Volke J, Klein-Hitpass L, Zwanziger D, Gunzer M, Jung S, Agace W, Kurts C, Engel DR. Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus.  Gut, doi: 10.1136/gutjnl-2017-313856 (2017).

Wehner S, Engel DR. Resident macrophages in the healthy and inflamed intestinal muscularis externa. Pflugers Arch. - Eur J Physiol, 469, 541-552 (2017).  

Klingberg A, Hasenberg A, Ludwig-Portugall I, Medyukhina A, Männ L, Brenzel A, Engel DR, Figge MT, Kurts C, Gunzer M. Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Usitng Lightsheet Microscopy. J Am Soc Nephrol, 28, 452-459 (2017).

2016

Hucke S, Herold M, Liebmann M, Freise N, Lindner M, Fleck AK, Zenker S, Thiebes S, Fernandez-Orth J, Buch D, Lues Hemmer B, Engel DR, Roth J, Kuhlmann T, Wiendl H, Klotz L. The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion. Acta Neuropathol, 132, 413-431 (2016).

Evers BD, Engel DR, Böhner, AM, Tittel AP, Krause TA., Heuser C, Garbi N., Kastenmüller W, Mack M, Tiegs G, Panzer U, Boor P, Ludwig-Portugall I, Kurts C. CD103+ kidney dendritic cells protect against crescentic glomerulonephritis by maintaining IL-10-producing regulatory T cells. J Am Soc Nephrol, 27, 3368-3382 (2016).

Zec K, Volke J, Vijitha N, Thiebes S, Gunzer M, Kurts C, Engel, DR, Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages. Pathogens, 5. (2016).

2015

Hasenberg A, Hasenberg M, Männ L, Neumann F, Borkenstein L, Stecher M, Kraus A, Engel DR, Klingberg A, Seddigh P, Abdullah Z, Klebow S, Engelmann S, Reinhold A, Brandau S, Seeling M, Waisman A, Schraven B, Gothert JR, Nimmerjahn F, Gunzer M. Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes. Nat Methods, 12, 445-52 (2015).

Engel DR, Krause TA, Snelgrove SL, Thiebes S, Hickey MJ, Boor P, Kitching AR, Kurts C. CX3CR1 Reduces Kidney Fibrosis by Inhibiting Local Proliferation of Profibrotic Macrophages. J Immunol, 194, 1628-38 (2015).

Böttcher JP, Beyer M, Meissner F, Abdullah Z, Sander J, Höchst B, Eickhoff S, Riekmann JC, Russo C, Bauer T, Flecken T, Giesen D, Engel D, Jung S, Busch DH, Protzer U, Thimme R, Mann M, Kurts C, Schultze JL, Kastenmüller W, Knolle PA. Functional classification of memory CD8(+) T cells by CX3CR1 expression. Nat Commun, 6:8306(2015).

Weisheit CK, Engel DR, Kurts C, Dendritic Cells and Macrophages: Sentinels in the Kidney. Clin J Am Soc Nephrol, 10, 1841-51 (2015).

2014

Krause TA, Alex AF, Engel DR, Kurts C, Eter N. VEGF-production by CCR2-dependent macrophages contributes to laser-induced choroidal neovascularization. PLoS One, 9, e94313 (2014).

Schiwon M, Weisheit C, Franken L, Gutweiler S, Dixit A, Meyer-Schwesinger C, Pohl JM, Maurice NJ, Thiebes S, Lorenz K, Quast T, Fuhrmann M, Baumgarten G, Lohse MJ, Opdenakker G, Bernhagen J, Bucala R, Panzer U, Kolanus W, Grone HJ, Garbi N, Kastenmuller W, Knolle PA, Kurts C, Engel, DR. Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium. Cell, 156, 456-68 (2014).

2013

Hochheiser, C. Heuser, T. A. Krause, S. Teteris, A. Ilias, C. Weisheit, F. Hoss, A. P. Tittel, P. A. Knolle, U. Panzer, D. R. Engel, P. L. Tharaux, Camille Kurts. Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression. J Clin Invest 123, 4242-4254 (2013).

Hoge, I. Yan, N. Janner, V. Schumacher, A. Chalaris, O. M. Steinmetz, D. R. Engel, J. Scheller, S. Rose-John, H. W. Mittrucker. IL-6 Controls the Innate Immune Response against Listeria monocytogenes via Classical IL-6 Signaling. J Immunol 190, 703-711 (2013).

Koscielny A, Engel D, Maurer J, Wehner S, Kurts C, Kalff JC. The role of lymphoid tissue in the attenuation of the postoperative ileus. Am J Physiol Gastrointest Liver Physiol., 304, G401-12 (2013).

2012

Koscielny A, Engel D, Maurer J, Wehner S, Kurts C, Kalff JC. The role of lymphoid tissue in the attenuation of the postoperative ileus. Am J Physiol Gastrointest Liver Physiol., 304, G401-12 (2012).

Tittel AP, Heuser C, Ohliger C, Llanto C, Yona S, Hämmerling GJ, Engel DR, Garbi N, Kurts C. Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice. Nat Methods, 9, 385-90 (2012).

Sicking EM, Fuss A, Uhlig S, Jirak P, Dijkman H, Wetzels J, Engel DR, Urzynicok T, Heidenreich S, Kriz W, Kurts C, Ostendorf T, Floege J, Smeets B, Moeller MJ. Subtotal ablation of parietal epithelial cells induces crescent formation. J Am Soc Nephrol, 23, 629-40 (2012).

Snelgrove SL, Kausman JY, Lo C, Lo C, Ooi JD, Coates PT, Hickey MJ, Holdsworth SR, Kurts C, Engel DR*, Kitching AR*. Renal dendritic cells adopt a pro-inflammatory phenotype in obstructive uropathy to activate T cells but do not directly contribute to fibrosis. Am J Pathol 180, 91-103 (2012). *contributed equally.

2011

Ooi JD, Snelgrove SL, Engel DR, Hochheiser K, Ludwig-Portugall I, Nozaki Y, O'Sullivan KM, Hickey MJ, Holdsworth SR, Kurts C, Kitching AR, Endogenous foxp3(+) T-regulatory cells suppress anti-glomerular basement membrane nephritis. Kidney Int, 79, 977-86 (2011).

Tittel AP, Heuser C, Ohliger C, Knolle PA, Engel DR, Kurts C. Kidney dendritic cells induce innate immunity against bacterial pyelonephritis. J Am Soc Nephrol, 22, 1435-41 (2011).

Hochheiser K*, Engel DR*, Hammerich L, Heymann F, Knolle PA, Panzer U, Kurts C. Kidney Dendritic Cells Become Pathogenic during Crescentic Glomerulonephritis with Proteinuria. J Am Soc Nephrol, 22, 306-16 (2011). *contributed equally

Teteris SA, Engel DR, Kurts C. Homeostatic and pathogenic role of renal dendritic cells. Kidney Int, 80, 139-45 (2011).

Koscielny A, Engel DR, Maurer J, Hirner A, Kurts C, Kalff JC. Impact of CCR7 on the gastrointestinal field effect. Am J Physiol Gastrointest Liver Physiol, 300, G665-75 (2011)

Koscielny, S. Wehner, D. R. Engel, C. Kurts, Judith Kalff. Isolation of T cells and dendritic cells from peripheral intestinal tissue, Peyer’s Patches and mesenteric lymph nodes in mice after intestinal manipulation. Protocol Exchange, doi: 10.1038/protex.2011.1201 (2011).

Wehner, A. Koscielny, T. O. Vilz, B. Stoffels, D. R. Engel, C. Kurts, Judith Kalff. Measurement of gastrointestinal and colonic transit in mice. Nat Protoc, doi: 10.1038/protex.2011.1219 (2011).

2010

Engel DR, Koscielny A, Wehner S, Maurer J, Schiwon M, Franken L, Schumak B, Limmer A, Sparwasser T, Hirner A, Knolle PA, Kalff JC, Kurts C. T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract. Nat Med, 16, 1407-13 (2010).

Bosschaerts T, Guilliams M, Stijlemans B, Morias Y, Engel D Tacke F, Hérin M, De Baetselier P, Beschin A. Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2, IFN-gamma and MyD88 signaling. PLoS Pathog, 6, e1001045 (2010).

2008

Engel DR, Maurer J, Tittel AP, Weisheit C, Cavlar T, Schumak B, Limmer A, van Rooijen N, Trautwein C, Tacke F, Kurts C. CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection. J Immunol 181, 5579-86 (2008).

Eter N, Engel DR, Meyer L, Helb HM, Roth F, Maurer J, Holz FG, Kurts C. In vivo visualization of dendritic cells, macrophages and microglial cells responding to laser-induced damage in the fundus of the eye. Invest Ophthalmol Vis Sci, 49, 3649-58(2008).

Scholz J, Lukacs-Kornek V, Engel DR, Specht S, Kiss E, Eitner F, Floege J, Groene HJ, Kurts C. Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis. J Am Soc Nephrol, 19, 527-37 (2008).

Lukacs-Kornek V, Engel D, Tacke F, Kurts C. The role of chemokines and their receptors in dendritic cell biology. Front Biosci, 13, 2238-52 (2008).

2006

Engel D, Dobrindt U, Tittel A, Peters P, Maurer J, Gütgemann I, Kaissling B, Kuziel W, Jung S, Kurts C. Tumor necrosis factor alpha- and inducible nitric oxide synthase-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection but are dispensable for bacterial clearance. Infect Immun, 74, 6100-7 (2006).

2005

Lang A, Benke D, Eitner F, Engel D, Ehrlich S, Breloer M, Hamilton-Williams E, Specht S, Hoerauf A, Floege J, von Bonin A, Kurts C. Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: in vivo evidence for an immunologic danger signal. J Am Soc Nephrol, 16, 383-91 (2005).

2004

Krüger T, Benke D, Eitner F, Lang A, Wirtz M, Hamilton-Williams EE, Engel D, Giese B, Müller-Newen G, Floege J, Kurts C. Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis. J Am Soc Nephrol, 15, 613-21 (2004).