Publications

Most Important Publications

 

 

 

 

 

 

 

 

 

 

 

 

Complete list of Publications

1          Silvestre-Roig, C., Chevre, R., Farjia, M., Bender, A., Vöcking, L. M., Richter, M., Hageb, A., Suerdick, V., Arenas, F., Braster, Q., Guzman, M., Sintes, J., Sharma, S., Lemnitzer, P., Tulotta, C., Börgeling, Y., Herrero-Cervera, A., Flueter, H., Reinartz Groba, S. N., Ahern, D., Osei-Sarpong, C., Zimmer, R., Alonso-Gonzalez, N., Ortega, E., Lienenklaus, S., Kalinke, U., Ludwig, S., Engel, D. R., Rosenbauer, F., Monaco, C., Dersch, P., Kibler, A., Cerutti, A., Chavakis, T., Benedito, R., Hidalgo, A., Jablonska, J., Palomino-Segura, M. & Soehnlein, O. Divergent granulopoiesis at extramedullary sites safeguards host defense. Sci Immunol, Accepted (2026).

2          Kolman, R., Voss, H., Bertovic, I., Peradinovic, J., Munitic, I., Engel, D. R., Shevchuk, O. & Jurak Begonja, A. Interleukin-1a alters megakaryocyte maturation, promotes emperipolesis, and induces a distinct proteomic profile. J Thromb Haemost, 24, 303-317 (2026). https://doi.org/10.1016/j.jtha.2025.08.037

3          Kerp, H., Siemes, S., Golchert, J., Engels, K., Hönes, G., Brix, K., Homuth, G., Völker, U., Moeller, L., Tacke, F., Führer, D., Engel, D. R. & Zwanziger, D. Thyroid hormone dysfunction imprints an immunological signature in the liver with kupffer cell activation during aging. Endocrine, Accepted (2026).

4          Widera, L., Spangenberg, P., Siemes, D., Bessler, S., Bottek, J., Voss, H., Novak, A., Hueser, D., Richter, M., Potthoff, A., Siebels, B., Moritz, M., Gocke, A., Thiebes, S., Tautges, S., Chavakis, T., Jablonska, J., Lämmermann, T., Gunzer, M., Schlüter, H., Hahn, J., Grüneboom, A., Soehnlein, O., Dreisewerd, K., Soltwisch, J., Shevchuk, O. & Engel, D. R. TSP1/TGF-β1 drives arachidonic acid metabolism to orchestrate neutrophil swarming. bioRxiv (2025). https://doi.org/10.1101/2025.11.25.688397

5          Spangenberg, P., Bessler, S., Widera, L., Bottek, J., Richter, M., Thiebes, S., Siemes, D., Krauss, S. D., Migas, L. G., Kasarla, S. S., Phapale, P., Kleesiek, J., Fuhrer, D., Moeller, L. C., Heuer, H., Van de Plas, R., Gunzer, M., Soehnlein, O., Soltwisch, J., Shevchuk, O., Dreisewerd, K. & Engel, D. R. msiFlow: automated workflows for reproducible and scalable multimodal mass spectrometry imaging and microscopy data analysis. Nat Commun, 16, 1065 (2025). https://doi.org/10.1038/s41467-024-55306-7

6          Siemes, D., Voss, H., Benvenuti, F., Simoncello, F., Kopczynski, D., Siebels, B., Schluter, H., Kollipara, L., Sickmann, A., Engel, D. R. & Shevchuk, O. A reference database enabling in-depth proteome and PTM analysis of mouse immune cells. Sci Data, 12, 596 (2025). https://doi.org/10.1038/s41597-025-04829-9

7          Pylaeva, E., Tollrian, L., Riedesel, J., Shevchuk, O., Thiel, I., Ozel, I., Kabankova, N., Voss, H., Siebels, B., Schluter, H., Haist, C., Hanenberg, H., Mattheis, S., Kurten, C., Sperandio, M., Kehrmann, J., Engel, D. R., Lang, S. & Jablonska, J. G-CSF/NAMPT signaling drives neutrophil dysfunction and enhances bacterial infection susceptibility in cancer patients. Nat Commun, 16, 11137 (2025). https://doi.org/10.1038/s41467-025-67471-4

8          Placke, J. M., Bottek, J., Varaljai, R., Shannan, B., Scharfenberg, S., Krisp, C., Spangenberg, P., Soun, C., Siemes, D., Borgards, L., Hoffmann, F., Zhao, F., Paschen, A., Schlueter, H., von Eggeling, F., Helfrich, I., Rambow, F., Ugurel, S., Tasdogan, A., Schadendorf, D., Engel, D. R. & Roesch, A. Spatial proteomics reveals sirtuin 1 to be a determinant of T-cell infiltration in human melanoma. Br J Dermatol, 192, 481-491 (2025). https://doi.org/10.1093/bjd/ljae433

9          Christ, R., Siemes, D., Zhao, S., Widera, L., Spangenberg, P., Lill, J., Thiebes, S., Bottek, J., Borgards, L., Pinho, A. G., Silva, N. A., Monteiro, S., Jorch, S. K., Gunzer, M., Siebels, B., Voss, H., Schluter, H., Shevchuk, O., Chen, J. & Engel, D. R. Inhibition of tumour necrosis factor alpha by Etanercept attenuates Shiga toxin-induced brain pathology. J Neuroinflammation, 22, 33 (2025). https://doi.org/10.1186/s12974-025-03356-z

10        Bader, A., Gao, J., Reiter, N., Siemes, D., Zehrer, A., Wei, X., Hepper, I., de Vega Gomez, E., Schmid, B., Forne, I., Engel, D. R., Walzog, B. & Maier-Begandt, D. SCAMP3 is essential for proper formation and function of neutrophil granules. J Leukoc Biol, 117 (2025). https://doi.org/10.1093/jleuko/qiaf153

11        Wenzek, C., Siemes, D., Hones, G. S., Pastille, E., Harting, N., Kaiser, F., Moeller, L. C., Engel, D. R., Westendorf, A. M. & Fuhrer, D. Lack of canonical thyroid hormone receptor alpha signaling changes regulatory T cell phenotype in female mice. iScience, 27, 110547 (2024). https://doi.org/10.1016/j.isci.2024.110547

12        Voss, H., Robert Engel, D., Wagenlehner, F. & Shevchuk, O. Discovery of Antimicrobial Peptides in Urinary Tract Infections. Eur Urol Focus, 10, 710-712 (2024). https://doi.org/10.1016/j.euf.2024.08.010

13        Von Vietinghoff, S., Shevchuk, O., Dobrindt, U., Engel, D. R., Jorch, S. K., Kurts, C., Miethke, T. & Wagenlehner, F. The global burden of antimicrobial resistance - urinary tract infections. Nephrol Dial Transplant, 39, 581-588 (2024). https://doi.org/10.1093/ndt/gfad233

14        Tuz, A. A., Ghosh, S., Karsch, L., Ttoouli, D., Sata, S. P., Ulusoy, O., Kraus, A., Hoerenbaum, N., Wolf, J. N., Lohmann, S., Zwirnlein, F., Kaygusuz, V., Lakovic, V., Tummes, H. L., Beer, A., Gallert, M., Thiebes, S., Qefalia, A., Cibir, Z., Antler, M., Korste, S., Haj Yehia, E., Michel, L., Rassaf, T., Kaltwasser, B., Abdelrahman, H., Mohamud Yusuf, A., Wang, C., Yin, D., Haeusler, L., Lueong, S., Richter, M., Engel, D. R., Stenzel, M., Soehnlein, O., Frank, B., Solo-Nomenjanahary, M., Ho-Tin-Noe, B., Siveke, J. T., Totzeck, M., Hoffmann, D., Gruneboom, A., Hagemann, N., Hasenberg, A., Desilles, J. P., Mazighi, M., Sickmann, A., Chen, J., Hermann, D. M., Gunzer, M. & Singh, V. Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion. Nat Cardiovasc Res, 3, 525-540 (2024). https://doi.org/10.1038/s44161-024-00462-8

15        Geist, D., Hones, G. S., Grund, S. C., Pape, J., Siemes, D., Spangenberg, P., Tolstik, E., Dorr, S., Spielmann, N., Fuchs, H., Gailus-Durner, V., Hrabe de Angelis, M., Mittag, J., Engel, D. R., Fuhrer, D., Lorenz, K. & Moeller, L. C. Canonical and Noncanonical Contribution of Thyroid Hormone Receptor Isoforms Alpha and Beta to Cardiac Hypertrophy and Heart Rate in Male Mice. Thyroid, 34, 785-795 (2024). https://doi.org/10.1089/thy.2023.0683

16        Engel, D. R., Wagenlehner, F. M. E. & Shevchuk, O. Scientific Advances in Understanding the Pathogenesis, Diagnosis, and Prevention of Urinary Tract Infection in the Past 10 Years. Infect Dis Clin North Am, 38, 229-240 (2024). https://doi.org/10.1016/j.idc.2024.03.002

17        Aust, A. C., Weigel, M., Herrmann, J. P., Shevchuk, O., Robert Engel, D., Dobrindt, U., Hain, T. & Wagenlehner, F. Influence of Kidney Environment Parameters on Antibiotic Efficacy Against Uropathogenic Escherichia coli. Eur Urol Focus, 10, 742-750 (2024). https://doi.org/10.1016/j.euf.2024.07.007

18        Zec, K., Thiebes, S., Bottek, J., Siemes, D., Spangenberg, P., Trieu, D. V., Kirstein, N., Subramaniam, N., Christ, R., Klein, D., Jendrossek, V., Loose, M., Wagenlehner, F., Jablonska, J., Bracht, T., Sitek, B., Budeus, B., Klein-Hitpass, L., Theegarten, D., Shevchuk, O. & Engel, D. R. Comparative transcriptomic and proteomic signature of lung alveolar macrophages reveals the integrin CD11b as a regulatory hub during pneumococcal pneumonia infection. Front Immunol, 14, 1227191 (2023). https://doi.org/10.3389/fimmu.2023.1227191

19        Xie, X., Patnana, P. K., Frank, D., Schutte, J., Al-Matary, Y., Kunstner, A., Busch, H., Ahmed, H., Liu, L., Engel, D. R., Duhrsen, U., Rosenbauer, F., Von Bubnoff, N., Lenz, G. & Khandanpour, C. Dose-dependent effect of GFI1 expression in the reconstitution and the differentiation capacity of HSCs. Front Cell Dev Biol, 11, 866847 (2023). https://doi.org/10.3389/fcell.2023.866847

20        Varaljai, R., Zimmer, L., Al-Matary, Y., Kaptein, P., Albrecht, L. J., Shannan, B., Brase, J. C., Gusenleitner, D., Amaral, T., Wyss, N., Utikal, J., Flatz, L., Rambow, F., Reinhardt, H. C., Dick, J., Engel, D. R., Horn, S., Ugurel, S., Sondermann, W., Livingstone, E., Sucker, A., Paschen, A., Zhao, F., Placke, J. M., Klose, J. M., Fendler, W. P., Thommen, D. S., Helfrich, I., Schadendorf, D. & Roesch, A. Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma. Nat Cancer, 4, 1292-1308 (2023). https://doi.org/10.1038/s43018-023-00610-2

21        Spangenberg, P., Hagemann, N., Squire, A., Forster, N., Krauss, S. D., Qi, Y., Mohamud Yusuf, A., Wang, J., Gruneboom, A., Kowitz, L., Korste, S., Totzeck, M., Cibir, Z., Tuz, A. A., Singh, V., Siemes, D., Struensee, L., Engel, D. R., Ludewig, P., Martins Nascentes Melo, L., Helfrich, I., Chen, J., Gunzer, M., Hermann, D. M. & Mosig, A. Rapid and fully automated blood vasculature analysis in 3D light-sheet image volumes of different organs. Cell Rep Methods, 3, 100436 (2023). https://doi.org/10.1016/j.crmeth.2023.100436

22        Siemes, D., Vancamp, P., Markova, B., Spangenberg, P., Shevchuk, O., Siebels, B., Schluter, H., Mayerl, S., Heuer, H. & Engel, D. R. Proteome Analysis of Thyroid Hormone Transporter Mct8/Oatp1c1-Deficient Mice Reveals Novel Dysregulated Target Molecules Involved in Locomotor Function. Cells, 12, 2487 (2023). https://doi.org/10.3390/cells12202487

23        Placke, J. M., Kimmig, M., Griewank, K., Herbst, R., Terheyden, P., Utikal, J., Pfohler, C., Ulrich, J., Kreuter, A., Mohr, P., Gutzmer, R., Meier, F., Dippel, E., Welzel, J., Engel, D. R., Kreft, S., Sucker, A., Lodde, G., Krefting, F., Stoffels, I., Klode, J., Roesch, A., Zimmer, L., Livingstone, E., Hadaschik, E., Becker, J. C., Weichenthal, M., Tasdogan, A., Schadendorf, D. & Ugurel, S. Correlation of tumor PD-L1 expression in different tissue types and outcome of PD-1-based immunotherapy in metastatic melanoma - analysis of the DeCOG prospective multicenter cohort study ADOREG/TRIM. EBioMedicine, 96, 104774 (2023). https://doi.org/10.1016/j.ebiom.2023.104774

24        Bouvain, P., Ding, Z., Kadir, S., Kleimann, P., Kluge, N., Tiren, Z. B., Steckel, B., Flocke, V., Zalfen, R., Petzsch, P., Wachtmeister, T., John, G., Subramaniam, N., Kramer, W., Strasdeit, T., Mehrabipour, M., Moll, J. M., Schubert, R., Ahmadian, M. R., Bonner, F., Boeken, U., Westenfeld, R., Engel, D. R., Kelm, M., Schrader, J., Kohrer, K., Grandoch, M., Temme, S. & Flogel, U. Non-invasive mapping of systemic neutrophil dynamics upon cardiovascular injury. Nat Cardiovasc Res, 2, 126-143 (2023). https://doi.org/10.1038/s44161-022-00210-w

25        Borgards, L., Siebels, B., Voss, H., Krisp, C., Schmitz, J., Schwarz, L., Siemes, D., Spangenberg, P., Bräsen, J. H., von Vietinghoff, S., Schlüter, H., Wagenlehner, F., Engel, D. R. & Shevchuk, O. Proteomic adaptations in the kidney reveal orchestration of local and secreted antimicrobial peptides in human pyelonephritis. bioRxiv (2023). https://doi.org/10.1101/2023.09.14.557715

26        Borgards, L., Siebels, B., Voss, H., Krisp, C., Schmitz, J., Schwarz, L., Siemes, D., Spangenberg, P., Bräsen, J. H., von Vietinghoff, S., Schlüter, H., Wagenlehner, F., Engel, D. R. & Shevchuk, O. Proteomic adaptations in the kidney reveal orchestration of local and secreted antimicrobial peptides in human pyelonephritis. bioRxiv, 2023.2009.2014.557715 (2023). https://doi.org/10.1101/2023.09.14.557715

27        Wenzek, C., Boelen, A., Westendorf, A. M., Engel, D. R., Moeller, L. C. & Fuhrer, D. The interplay of thyroid hormones and the immune system - where we stand and why we need to know about it. Eur J Endocrinol, 186, R65-R77 (2022). https://doi.org/10.1530/EJE-21-1171

28        Fleig, S., Kapanadze, T., Bernier-Latmani, J., Lill, J. K., Wyss, T., Gamrekelashvili, J., Kijas, D., Liu, B., Husing, A. M., Bovay, E., Jirmo, A. C., Halle, S., Ricke-Hoch, M., Adams, R. H., Engel, D. R., von Vietinghoff, S., Forster, R., Hilfiker-Kleiner, D., Haller, H., Petrova, T. V. & Limbourg, F. P. Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures.Nat Commun, 13, 2022 (2022). https://doi.org/10.1038/s41467-022-29701-x

29        Cheung, P. F., Yang, J., Fang, R., Borgers, A., Krengel, K., Stoffel, A., Althoff, K., Yip, C. W., Siu, E. H. L., Ng, L. W. C., Lang, K. S., Cham, L. B., Engel, D. R., Soun, C., Cima, I., Scheffler, B., Striefler, J. K., Sinn, M., Bahra, M., Pelzer, U., Oettle, H., Markus, P., Smeets, E. M. M., Aarntzen, E., Savvatakis, K., Liffers, S. T., Lueong, S. S., Neander, C., Bazarna, A., Zhang, X., Paschen, A., Crawford, H. C., Chan, A. W. H., Cheung, S. T. & Siveke, J. T. Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression. Nat Commun, 13, 156 (2022).https://doi.org/10.1038/s41467-021-27088-9

30        Subramaniam, N., Bottek, J., Thiebes, S., Zec, K., Kudla, M., Soun, C., de Dios Panal, E., Lill, J. K., Pfennig, A., Herrmann, R., Bruderek, K., Rahmann, S., Brandau, S., Johansson, P., Reinhardt, H. C., Durig, J., Seiffert, M., Bracht, T., Sitek, B. & Engel, D. R. Proteomic and bioinformatic profiling of neutrophils in CLL reveals functional defects that predispose to bacterial infections. Blood Adv, 5, 1259-1272 (2021). https://doi.org/10.1182/bloodadvances.2020002949

31        Scheunemann, J. F., Reichwald, J. J., Korir, P. J., Kuehlwein, J. M., Jenster, L. M., Hammerschmidt-Kamper, C., Lewis, M. D., Klocke, K., Borsche, M., Schwendt, K. E., Soun, C., Thiebes, S., Limmer, A., Engel, D. R., Mueller, A. K., Hoerauf, A., Hubner, M. P. & Schumak, B. Eosinophils Suppress the Migration of T Cells Into the Brain of Plasmodium berghei-Infected Ifnar1(-/-) Mice and Protect Them From Experimental Cerebral Malaria. Front Immunol, 12, 711876 (2021). https://doi.org/10.3389/fimmu.2021.711876

32        Placke, J. M., Soun, C., Bottek, J., Herbst, R., Terheyden, P., Utikal, J., Pfohler, C., Ulrich, J., Kreuter, A., Pfeiffer, C., Mohr, P., Gutzmer, R., Meier, F., Dippel, E., Weichenthal, M., Zimmer, L., Livingstone, E., Becker, J. C., Lodde, G., Sucker, A., Griewank, K., Horn, S., Hadaschik, E., Roesch, A., Schadendorf, D., Engel, D. R. & Ugurel, S. Digital Quantification of Tumor PD-L1 Predicts Outcome of PD-1-Based Immune Checkpoint Therapy in Metastatic Melanoma. Front Oncol, 11, 741993 (2021). https://doi.org/10.3389/fonc.2021.741993

33        Lill, J. K., Thiebes, S., Pohl, J. M., Bottek, J., Subramaniam, N., Christ, R., Soun, C., Gueler, F., Zwanziger, D., Hoffmann, F., von Eggeling, F., Bracht, T., Sitek, B., Hickey, M. J., Hofnagel, O. & Engel, D. R. Tissue-resident macrophages mediate neutrophil recruitment and kidney injury in shiga toxin-induced hemolytic uremic syndrome. Kidney Int, 100, 349-363 (2021). https://doi.org/10.1016/j.kint.2021.03.039

34        Bottek, J., Soun, C., Lill, J. K., Dixit, A., Thiebes, S., Beerlage, A. L., Horstmann, M., Urbanek, A., Heuer, H., Uszkoreit, J., Eisenacher, M., Bracht, T., Sitek, B., Hoffmann, F., Vijitha, N., von Eggeling, F. & Engel, D. R. Spatial proteomics revealed a CX3CL1-dependent crosstalk between the urothelium and relocated macrophages through IL-6 during an acute bacterial infection in the urinary bladder. Mucosal Immunol, 13, 702-714 (2020). https://doi.org/10.1038/s41385-020-0269-7

35        Wiesemann, A., Ketteler, J., Slama, A., Wirsdorfer, F., Hager, T., Rock, K., Engel, D. R., Fischer, J. W., Aigner, C., Jendrossek, V. & Klein, D. Inhibition of Radiation-Induced Ccl2 Signaling Protects Lungs from Vascular Dysfunction and Endothelial Cell Loss. Antioxid Redox Signal, 30, 213-231 (2019). https://doi.org/10.1089/ars.2017.7458

36        Vijitha, N. & Engel, D. R. Remote control of Th 17 responses: The lung-CNS axis during EAE. J Leukoc Biol (2019). https://doi.org/10.1002/JLB.1CE0219-072R

37        Merz, S. F., Korste, S., Bornemann, L., Michel, L., Stock, P., Squire, A., Soun, C., Engel, D. R., Detzer, J., Lorchner, H., Hermann, D. M., Kamler, M., Klode, J., Hendgen-Cotta, U. B., Rassaf, T., Gunzer, M. & Totzeck, M. Publisher Correction: Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response. Nat Commun, 10, 2768 (2019). https://doi.org/10.1038/s41467-019-10804-x

38        Merz, S. F., Korste, S., Bornemann, L., Michel, L., Stock, P., Squire, A., Soun, C., Engel, D. R., Detzer, J., Lorchner, H., Hermann, D. M., Kamler, M., Klode, J., Hendgen-Cotta, U. B., Rassaf, T., Gunzer, M. & Totzeck, M. Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response. Nat Commun, 10, 2312 (2019). https://doi.org/10.1038/s41467-019-10338-2

39        Gruneboom, A., Hawwari, I., Weidner, D., Culemann, S., Muller, S., Henneberg, S., Brenzel, A., Merz, S., Bornemann, L., Zec, K., Wuelling, M., Kling, L., Hasenberg, M., Voortmann, S., Lang, S., Baum, W., Ohs, A., Kraff, O., Quick, H. H., Jager, M., Landgraeber, S., Dudda, M., Danuser, R., Stein, J. V., Rohde, M., Gelse, K., Garbe, A. I., Adamczyk, A., Westendorf, A. M., Hoffmann, D., Christiansen, S., Engel, D. R., Vortkamp, A., Kronke, G., Herrmann, M., Kamradt, T., Schett, G., Hasenberg, A. & Gunzer, M. A network of trans-cortical capillaries as mainstay for blood circulation in long bones. Nat Metab, 1, 236-250 (2019). https://doi.org/10.1038/s42255-018-0016-5

40        Pohl, J. M., Volke, J. K., Thiebes, S., Brenzel, A., Fuchs, K., Beziere, N., Ehrlichmann, W., Pichler, B. J., Squire, A., Gueler, F. & Engel, D. R. CCR2-dependent Gr1(high) monocytes promote kidney injury in shiga toxin-induced hemolytic uremic syndrome in mice. Eur J Immunol, 48, 990-1000 (2018). https://doi.org/10.1002/eji.201747138

41        Dixit, A., Bottek, J., Beerlage, A. L., Schuettpelz, J., Thiebes, S., Brenzel, A., Garbers, C., Rose-John, S., Mittrucker, H. W., Squire, A. & Engel, D. R. Frontline Science: Proliferation of Ly6C(+) monocytes during urinary tract infections is regulated by IL-6 trans-signaling. J Leukoc Biol, 103, 13-22 (2018). https://doi.org/10.1189/jlb.3HI0517-198R

42        Wehner, S. & Engel, D. R. Resident macrophages in the healthy and inflamed intestinal muscularis externa. Pflugers Arch, 469, 541-552 (2017). https://doi.org/10.1007/s00424-017-1948-4

43        Pohl, J. M., Gutweiler, S., Thiebes, S., Volke, J. K., Klein-Hitpass, L., Zwanziger, D., Gunzer, M., Jung, S., Agace, W. W., Kurts, C. & Engel, D. R. Irf4-dependent CD103(+)CD11b(+) dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus. Gut, 66, 2110-2120 (2017). https://doi.org/10.1136/gutjnl-2017-313856

44        Klingberg, A., Hasenberg, A., Ludwig-Portugall, I., Medyukhina, A., Mann, L., Brenzel, A., Engel, D. R., Figge, M. T., Kurts, C. & Gunzer, M. Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Using Lightsheet Microscopy. J Am Soc Nephrol, 28, 452-459 (2017). https://doi.org/10.1681/ASN.2016020232

45        Zec, K., Volke, J., Vijitha, N., Thiebes, S., Gunzer, M., Kurts, C. & Engel, D. R. Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages. Pathogens, 5 (2016). https://doi.org/10.3390/pathogens5010015

46        Hucke, S., Herold, M., Liebmann, M., Freise, N., Lindner, M., Fleck, A. K., Zenker, S., Thiebes, S., Fernandez-Orth, J., Buck, D., Luessi, F., Meuth, S. G., Zipp, F., Hemmer, B., Engel, D. R., Roth, J., Kuhlmann, T., Wiendl, H. & Klotz, L. The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion. Acta Neuropathol, 132, 413-431 (2016). https://doi.org/10.1007/s00401-016-1593-6

47        Evers, B. D., Engel, D. R., Bohner, A. M., Tittel, A. P., Krause, T. A., Heuser, C., Garbi, N., Kastenmuller, W., Mack, M., Tiegs, G., Panzer, U., Boor, P., Ludwig-Portugall, I. & Kurts, C. CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells. J Am Soc Nephrol, 27, 3368-3382 (2016). https://doi.org/10.1681/ASN.2015080873

48        Weisheit, C. K., Engel, D. R. & Kurts, C. Dendritic Cells and Macrophages: Sentinels in the Kidney. Clin J Am Soc Nephrol, 10, 1841-1851 (2015). https://doi.org/10.2215/CJN.07100714

49        Hasenberg, A., Hasenberg, M., Mann, L., Neumann, F., Borkenstein, L., Stecher, M., Kraus, A., Engel, D. R., Klingberg, A., Seddigh, P., Abdullah, Z., Klebow, S., Engelmann, S., Reinhold, A., Brandau, S., Seeling, M., Waisman, A., Schraven, B., Gothert, J. R., Nimmerjahn, F. & Gunzer, M. Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes. Nat Methods, 12, 445-452 (2015). https://doi.org/10.1038/nmeth.3322

50        Engel, D. R., Krause, T. A., Snelgrove, S. L., Thiebes, S., Hickey, M. J., Boor, P., Kitching, A. R. & Kurts, C. CX3CR1 Reduces Kidney Fibrosis by Inhibiting Local Proliferation of Profibrotic Macrophages. J immunol, 194, 1628-1638 (2015). https://doi.org/10.4049/jimmunol.1402149

51        Bottcher, J. P., Beyer, M., Meissner, F., Abdullah, Z., Sander, J., Hochst, B., Eickhoff, S., Rieckmann, J. C., Russo, C., Bauer, T., Flecken, T., Giesen, D., Engel, D., Jung, S., Busch, D. H., Protzer, U., Thimme, R., Mann, M., Kurts, C., Schultze, J. L., Kastenmuller, W. & Knolle, P. A. Functional classification of memory CD8(+) T cells by CX3CR1 expression. Nat Commun, 6, 8306 (2015). https://doi.org/10.1038/ncomms9306

52        Schiwon, M., Weisheit, C., Franken, L., Gutweiler, S., Dixit, A., Meyer-Schwesinger, C., Pohl, J. M., Maurice, N. J., Thiebes, S., Lorenz, K., Quast, T., Fuhrmann, M., Baumgarten, G., Lohse, M. J., Opdenakker, G., Bernhagen, J., Bucala, R., Panzer, U., Kolanus, W., Grone, H. J., Garbi, N., Kastenmuller, W., Knolle, P. A., Kurts, C. & Engel, D. R. Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium. Cell, 156, 456-468 (2014). https://doi.org/10.1016/j.cell.2014.01.006

53        Krause, T. A., Alex, A. F., Engel, D. R., Kurts, C. & Eter, N. VEGF-production by CCR2-dependent macrophages contributes to laser-induced choroidal neovascularization. PLoS One, 9, e94313 (2014). https://doi.org/10.1371/journal.pone.0094313

54        Hoge, J., Yan, I., Janner, N., Schumacher, V., Chalaris, A., Steinmetz, O. M., Engel, D. R., Scheller, J., Rose-John, S. & Mittrucker, H. W. IL-6 Controls the Innate Immune Response against Listeria monocytogenes via Classical IL-6 Signaling. J immunol, 190, 703-711 (2013). https://doi.org/10.4049/jimmunol.1201044

55        Hochheiser, K., Heuser, C., Krause, T. A., Teteris, S., Ilias, A., Weisheit, C., Hoss, F., Tittel, A. P., Knolle, P. A., Panzer, U., Engel, D. R., Tharaux, P. L. & Kurts, C. Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression. J clin invest, 123, 4242-4254 (2013). https://doi.org/10.1172/JCI70143

56        Tittel, A. P., Heuser, C., Ohliger, C., Llanto, C., Yona, S., Hämmerling, G. J., Engel, D. R., Garbi, N. & Kurts, C. Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice. Nat Methods, 9, 385-390 (2012). https://doi.org/10.1038/nmeth.1905

57        Snelgrove, S. L., Kausman, J. Y., Lo, C., Lo, C., Ooi, J. D., Coates, P. T., Hickey, M. J., Holdsworth, S. R., Kurts, C., Engel, D. R. & Kitching, A. R. Renal dendritic cells adopt a pro-inflammatory phenotype in obstructive uropathy to activate T cells but do not directly contribute to fibrosis. Am J Pathol, 180, 91-103 (2012). https://doi.org/10.1016/j.ajpath.2011.09.039

58        Sicking, E. M., Fuss, A., Uhlig, S., Jirak, P., Dijkman, H., Wetzels, J., Engel, D. R., Urzynicok, T., Heidenreich, S., Kriz, W., Kurts, C., Ostendorf, T., Floege, J., Smeets, B. & Moeller, M. J. Subtotal ablation of parietal epithelial cells induces crescent formation. J Am Soc Nephrol, 23, 629-640 (2012). https://doi.org/10.1681/ASN.2011050449

59        Koscielny, A., Engel, D., Maurer, J., Wehner, S., Kurts, C. & Kalff, J. C. The role of lymphoid tissue in the attenuation of the postoperative ileus. Am J Physiol Gastrointest Liver Physiol, 304, G401-412 (2012). https://doi.org/10.1152/ajpgi.00161.2012

60        Wehner, S., Koscielny, A., Vilz, T. O., Stoffels, B., Engel, D. R., Kurts, C. & Kalff, J. Measurement of gastrointestinal and colonic transit in mice. Nat Protoc, doi: 10.1038/protex.2011.1219 (2011). https://doi.org/10.1038/protex.2011.219

61        Tittel, A. P., Heuser, C., Ohliger, C., Knolle, P. A., Engel, D. R. & Kurts, C. Kidney dendritic cells induce innate immunity against bacterial pyelonephritis. J Am Soc Nephrol, 22, 1435-1441 (2011). https://doi.org/10.1681/ASN.2010101072

62        Teteris, S. A., Engel, D. R. & Kurts, C. Homeostatic and pathogenic role of renal dendritic cells. Kidney Int, 80, 139-145 (2011). https://doi.org/10.1038/ki.2011.129

63        Ooi, J. D., Snelgrove, S. L., Engel, D. R., Hochheiser, K., Ludwig-Portugall, I., Nozaki, Y., O'Sullivan, K. M., Hickey, M. J., Holdsworth, S. R., Kurts, C. & Kitching, A. R. Endogenous foxp3(+) T-regulatory cells suppress anti-glomerular basement membrane nephritis. Kidney Int, 79, 977-986 (2011). https://doi.org/10.1038/ki.2010.541

64        Koscielny, A., Wehner, S., Engel, D. R., Kurts, C. & Kalff, J. Isolation of T cells and dendritic cells from peripheral intestinal tissue, Peyer’s Patches and mesenteric lymph nodes in mice after intestinal manipulation. Protocol Exchange (2011). https://doi.org/10.1038/protex.2011.201

65        Koscielny, A., Engel, D. R., Wehner, S., Kurts, C. & Kalff, J. C. The postoperative ileus – an immunological disease. J Am Coll Surg, 213, S21 (2011). https://doi.org/10.1016/j.jamcollsurg.2011.06.030

66        Koscielny, A., Engel, D., Maurer, J., Hirner, A., Kurts, C. & Kalff, J. C. Impact of CCR7 on the gastrointestinal field effect. Am J Physiol Gastrointest Liver Physiol, 300, G665-675 (2011). https://doi.org/10.1152/ajpgi.00224.2010

67        Hochheiser, K., Engel, D. R., Hammerich, L., Heymann, F., Knolle, P. A., Panzer, U. & Kurts, C. Kidney Dendritic Cells Become Pathogenic during Crescentic Glomerulonephritis with Proteinuria. J Am Soc Nephrol, 22, 306-316 (2011). https://doi.org/10.1681/ASN.2010050548

68        Koscielny, A., Engel, D., Kurts, C. & Kalff, J. C. The gastrointestinal field effect: Is it immune-mediated? J Am Coll Surg, 211, 18-19 (2010). https://doi.org/10.1016/j.jamcollsurg.2010.06.042

69        Engel, D. R., Koscielny, A., Wehner, S., Maurer, J., Schiwon, M., Franken, L., Schumak, B., Limmer, A., Sparwasser, T., Hirner, A., Knolle, P. A., Kalff, J. C. & Kurts, C. T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract. Nat Med, 16, 1407-1413 (2010). https://doi.org/10.1038/nm.2255

70        Bosschaerts, T., Guilliams, M., Stijlemans, B., Morias, Y., Engel, D., Tacke, F., Hérin, M., De Baetselier, P. & Beschin, A. Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2, IFN-gamma and MyD88 signaling. PLoS Pathog, 6 (2010). https://doi.org/10.1371/journal.ppat.1001045

71        Guilliams, M., Stijlemans, B., Morias, Y., Engel, D., Tacke, F., Bucala, R., Van Den Driessche, T., Chuah, M. K., De Baetselier, P. & Beschin, A. Differentiation, activation and function of CD11b+Ly6C+ TNF/iNOS-producing dendritic cells during parasitic infection. Cytokine, 48, 135-135 (2009). https://doi.org/10.1016/j.cyto.2009.07.571

72        Scholz, J., Lukacs-Kornek, V., Engel, D. R., Specht, S., Kiss, E., Eitner, F., Floege, J., Groene, H. J. & Kurts, C. Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis. J Am Soc Nephrol, 19, 527-537 (2008). https://doi.org/10.1681/ASN.2007060684

73        Lukacs-Kornek, V., Engel, D., Tacke, F. & Kurts, C. The role of chemokines and their receptors in dendritic cell biology. Front Biosci, 13, 2238-2252 (2008). https://doi.org/10.2741/2838

74        Eter, N., Engel, D. R., Meyer, L., Helb, H. M., Roth, F., Maurer, J., Holz, F. G. & Kurts, C. In vivo visualization of dendritic cells, macrophages, and microglial cells responding to laser-induced damage in the fundus of the eye. Invest Ophthalmol Vis Sci, 49, 3649-3658 (2008). https://doi.org/10.1167/iovs.07-1322

75        Engel, D. R., Maurer, J., Tittel, A. P., Weisheit, C., Cavlar, T., Schumak, B., Limmer, A., van Rooijen, N., Trautwein, C., Tacke, F. & Kurts, C. CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection. J immunol, 181, 5579-5586 (2008). https://doi.org/10.4049/jimmunol.181.8.5579

76        Nagy, G., Engel, D., Lehmann, A., Kurts, C., Emody, L., Hacker, J. & Dobrindt, U. Functional characterization of antigen 43 variants of Escherichia coli. Int J Med Microbiol, 296, 127-127 (2006). https://doi.org/10.1128/IAI.01952-06

77        Koscielny, A. J., Engel, D., Wehner, S., Kurts, C. & Kalff, J. Intestinal dendritic cells (DC) and CCR7 are centrally involved in the gastrointestinal field effect. J Am Coll Surg, 203, S16 (2006). https://doi.org/10.1016/j.jamcollsurg.2006.05.037

78        Engel, D., Dobrindt, U., Tittel, A., Peters, P., Maurer, J., Gutgemann, I., Kaissling, B., Kuziel, W., Jung, S. & Kurts, C. Tumor necrosis factor alpha- and inducible nitric oxide synthase-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection but are dispensable for bacterial clearance. Infect Immun, 74, 6100-6107 (2006). https://doi.org/10.1128/IAI.00881-06

79        Lang, A., Benke, D., Eitner, F., Engel, D., Ehrlich, S., Breloer, M., Hamilton-Williams, E., Specht, S., Hoerauf, A., Floege, J., von Bonin, A. & Kurts, C. Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: in vivo evidence for an immunologic danger signal. J Am Soc Nephrol, 16, 383-391 (2005). https://doi.org/10.1681/ASN.2004040276

80        Kruger, T., Benke, D., Eitner, F., Lang, A., Wirtz, M., Hamilton-Williams, E. E., Engel, D., Giese, B., Muller-Newen, G., Floege, J. & Kurts, C. Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis. J Am Soc Nephrol, 15, 613-621 (2004). https://doi.org/10.1097/01.asn.0000114553.36258.91